3D skin models at Alcyomics
Skin models play a crucial role in pharmaceutical research, particularly in the field of dermatology and topical drug development. These models provide a way to study the effects of drugs, cosmetics, and other substances on the skin in a controlled environment without the need for human or animal subjects.
Here at Alcyomics we have 3 types of skin models which can be used for your toxicology and mechanistic testing.
- 3D Human Skin Equivalent (HSE): HSE is a three-dimensional model that closely mimics human skin structure and function. Our full-thickness skin models comprise both the epidermis and dermis and are developed by co-culturing keratinocytes and fibroblasts. These models allow for the investigation of drug absorption, toxicity, irritation, efficacy, metabolism, and the interaction between skin layers.
- Tissue Skin explant Models: Our skin explant models are developed by culturing human skin from volunteer tissue donations. All of our donated tissues are taken immediately before the experiment begins to ensure perfect tissue health and viability. Our tissue volunteers come from a wide range of demographics, allowing you to tailor your research. These models provide the most realistic representation of the skin’s physiology and are used to study drug penetration, metabolism, toxicity, and inflammation.
- Reconstructed Human Epidermis (RHE): RHE models consist of only the epidermal layer of human skin, which is reconstructed in the laboratory using primary human keratinocytes. RHE models are frequently employed to assess the irritation potential of topical substances and evaluate their effect on skin barrier function.
These skin models provide valuable tools for preclinical testing, reducing the need for animal testing and enhancing the efficiency of drug discovery and development.
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