3D Skin models

Alcyomics 3D skin models

In the dynamic world of pre-clinical research, the emergence of 3D skin models is reshaping the way we study skin biology and assess therapeutic interventions. Let's delve into the transformative power of these models and their significance in advancing dermatological research.

Unlike traditional 2D cell cultures, 3D skin models provide a more physiologically relevant representation of human skin. They mimic the intricate architecture and cellular interactions found in vivo, making them invaluable tools for studying skin health and disease.

Our skin models are cultured in-house in a 96 well format allowing for large sample sizes per batch.

Models can be cultured from both neonatal and adult cell lineages

Applications in Pre-Clinical Research:

Drug Screening: These models allow for efficient screening of potential therapies, providing insights into drug efficacy and toxicity before advancing to clinical trials.

Example readouts include;

   1. Collagen/ ECM deposition assesment,
   2. Matrix remodelling,
   3. Inflammatory responses,
   4. Epidermal thickness
   5. UV exposure induced damage
   6. Wound healing 

Toxicology Studies: 3D skin models offer a platform to assess the safety of cosmetic and pharmaceutical products, reducing the need for animal testing. Endpoints can include histological assesment alongside MTT and LDH assays etc. 

Key Features of 3D Skin Models:

Tissue Complexity: These models capture the complexity of skin tissue, including the epidermis, dermis, and interactions between different cell types.

Functional Assays: Researchers can perform functional assays, such as barrier function assessments and immune response studies, within a more relevant context.

Precision and Realism: 3D skin models bridge the gap between in vitro and in vivo studies, providing a higher level of realism for more accurate research outcomes.

Reduced Animal Use: By offering a human-relevant platform for testing, 3D skin models contribute to the reduction of animal testing in dermatological research.
Histology of Alcyomics 3D skin models, epidermis shows clear stratification and barrier formation
Key protein characterisation of Alcyomics 3D skin models demonstrates tissue relevant structure and protein expression profiles. Extensive ECM is seen depositied within the 3D scaffold structure alongside efficient barrier formation and keratinocyte differentation
Heat shock protein 70 (HSP70) staining of 3D tissue models in response to toxic monoclonal antibody exposure
The effect of ROCK inhibitors on epidermal thickness
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