Alcyomics 3D skin models
Unlike traditional 2D cell cultures, 3D skin models provide a more physiologically relevant representation of human skin. They mimic the intricate architecture and cellular interactions found in vivo, making them invaluable tools for studying skin health and disease.
Our skin models are cultured in-house in a 96 well format allowing for large sample sizes per batch.
Models can be cultured from both neonatal and adult cell lineages
Applications in Pre-Clinical Research:
Drug Screening: These models allow for efficient screening of potential therapies, providing insights into drug efficacy and toxicity before advancing to clinical trials.
Example readouts include;
1. Collagen/ ECM deposition assesment,
2. Matrix remodelling,
3. Inflammatory responses,
4. Epidermal thickness
5. UV exposure induced damage
6. Wound healing
Toxicology Studies: 3D skin models offer a platform to assess the safety of cosmetic and pharmaceutical products, reducing the need for animal testing. Endpoints can include histological assesment alongside MTT and LDH assays etc.
Key Features of 3D Skin Models:
Tissue Complexity: These models capture the complexity of skin tissue, including the epidermis, dermis, and interactions between different cell types.
Functional Assays: Researchers can perform functional assays, such as barrier function assessments and immune response studies, within a more relevant context.
Precision and Realism: 3D skin models bridge the gap between in vitro and in vivo studies, providing a higher level of realism for more accurate research outcomes.
Reduced Animal Use: By offering a human-relevant platform for testing, 3D skin models contribute to the reduction of animal testing in dermatological research.