Skimune® with cosmetic product X
Skimune® can be used to study sensitisation of compounds used in the cosmetic industry. The assay can detect tissue damage resulting from cytokine release from stimulated immune cells in response to cosmetic actives or compounds, including complex mixtures.
Our client was involved in the development of cosmetics using natural ingredients. Alcyomics was engaged to help generate human safety data and assess any potential adverse immune responses to repeat doses of a novel product (product X) prior to first use in man. Product X had been developed for topical application; the effect of repeat dosage of product X was investigated in the presence of immune cells.
Alcyomics demonstrated that upon repeat exposure this product had the potential to cause an adverse immune response and therefore not safe in its present formulation for human application. For this client we also provided T cell proliferation assays which correlated with, and confirmed, the Skimune® results.
The data showed the usefulness of our screening assays (T-cell proliferation assays) and the Skimune® assay in the development of cosmetic actives or compounds.