Antibody Drug Conjugates
Photosensitivity assessment of Antibody Drug Conjugates
Benefits of the Skimune® assay
Detection of clinically relevant celluar immune responses
Validated in a number of case studiesAvailable in combination with complementary assays
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Our client was involved in the development of a panel of antibody drug conjugates. In addition to the standard Skimune® skin damage histopathology readouts, the client was interested in the effect of these compounds on melanin production. In response, we modified our flagship Skimune® assay to deliver a UV-dependent melanin readout.
Using a semi-automated image analysis system, melanin signals were quantified from H&E images. The results demonstrated increased melanin production as well as increased damage in the skin due to the client compounds.
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