Our services are unique to the biotechnology industry
Alcyomics offers unique tools for the Pharmaceutical (Skimune®Pharm and Skimune®Mab), Cosmetic (Skimune®Cosm) and Chemical Industries (Skimune®Chem). The Skimune® technologies are a series of human in vitro assays for immunogenicity, hypersensitivity, allergenicity, efficacy and potency assessment. Our assays detect immune responses and predict how the immune system would respond upon exposure to the test compound.
Alcyomics is committed to providing safety and efficacy assessment services to advance the success of your products by aiding the understanding of immune responses to drugs and novel compounds including monoclonal antibodies (Skimune®Mab) biosimilars and aptamers. The assays also reduce the need for extensive animal testing.
Skimune®Pharm – is a pre-clinical/clinical service tool. It is designed to predict first in-man adverse immune or allergic responses to new therapeutics. Skimune®Pharm is a human in vitro skin explant assay which uses fresh whole blood and tissue from the same individual (autologous system) to predict allergenicity. Read more
Skimune®Cosm – is a human in vitro skin explant assay which consists of human peripheral mononuclear cells co-cultured with normal human skin tissue from the same donor in the presence of the test compound. Read more
Skimune®Chem – is a safety assessment tool for testing cosmetics or household products. Skimune®Chem is a non-animal human in vitro skin explant assay capable of determining if the test chemical has the potential to provoke an immune response and react with the skin causing histological damage which is symptomatic of skin allergy. Read more
Skimune®Mab – Alcyomics have developed a human in vitro skin explant assay to determine efficacy, potency, dose responses and immunogenicity of therapeutics, including monoclonal antibodies, vaccines, aptamers and adjuvants. Read more
Alcyomics also provide Problem Solving Consultancy Services and a range of assays associated with immune-monitoring and immune investigation.
Immunogenicity testing services
Skimune spiecialise in immunogenicity testing, with the focus on safety assessment of monoclonal antibodies and novel drugs and chemicals, detection of adverse reactions, potency assessment, dose responses
Efficacy testing of immunomodulators
Assessment of immune suppressant activity of new immunomodulators, investigate mode of action and evaluation of compound efficacy. By studying the effect of the drug or compound in our in vitro human assays, additional information to that provided by the use of animal models alone will aid in determining safety and efficacy as well as individual variation and mode of action
Discrimination between sensitisers and non-sensitisers and allergen versus non-allergen in one test, potency assessment, screening assays (up to 30 compounds screened in one assay)
Potency determination, dose, time and exposure level investigations
First in man tests-pre-clinical trial testing
Human in vitro safety testing before in vivo clinical trials, adverse reaction testing, dose determination, immunomodulatory effects. The goal of pre-clinical testing is to “fail early, fail cheap”, so that inappropriate drug candidates can be identified and eliminated avoiding expensive development costs during commercialisation
Pre-treatment human in vitro testing to determine patient responses aid in patient selection for clinical trials
T cell proliferation assays, T regulatory cell analysis (inhibition assays, phenotype analysis), peripheral blood mononuclear cell subset analysis including DC and NK subsets and intracellular staining, cell subset isolation via magnetic beads and cell viability assessment
Cytokine multiplex assays via Luminex, FACS, ELISA, ELISPOT, whole blood cytokine assays
Additional functional tests investigating mode of action
mRNA and microRNA analysis on cells and tissue, immunohistochemistry, biomarker identification, aiding in drug discovery
Safety assessment service
At Alcyomics we can customise our service to meet our clients safety testing requirements. A safety testing protocol can be designed after detailed discussion and agreement between our scientific team and client, ensuring delivery of the best possible service. The expertise of our scientific team enables us to additionally offer our clients customised assay development specific to answering their safety questions.
Our consultancy service can guide clients with appropriate study design, advise on the clinical relevance of the in vitro data generated from the assays and suggest additional tests which may be of value in further understanding the mode of action of the compounds. To find out more about our Unique Services please Contact Us