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Reference and Patents

Patents:

European Patent: 2524227
UK Patent Application: 130348.5
International Filed Patent: PCT/GB2011/052312 Skin Explant Assay
US Patent application no 13/989,581 Skin Explant Assay

References:

  1. Sviland L, Dickinson AM, Carey PJ, Pearson ADJ, Proctor SJ. An in vitro predictive test for clinical graft versus host disease in allogeneic bone marrow transplant recipients. Bone Marrow Transplant (1990) 5:105-109. http://www.ncbi.nlm.nih.gov/pubmed/1968774
  1. Dickinson AM, Sviland L, Dunn J, Carey P, Proctor SJ. Demonstration of direct involvement of cytokines in graft versus host reactions using an in vitro human skin explant model. Bone Marrow Transplant (1991) 7:209- 216. http://www.ncbi.nlm.nih.gov/pubmed/1829387
  1. Dickinson AM, Sviland L, Jackson G, Usher P, Taylor P, Dunn J, Hamilton PJ, Proctor SJ. Cytokine involvement in predicting clinical graft versus host disease (GvHD) in allogeneic bone marrow transplant recipients. Bone Marrow Transplant (1994) 13(1):65-70. http://www.ncbi.nlm.nih.gov/pubmed/8019455
  1. Dickinson AM,Sviland L, Jackson G, Dunn, Stephens, Proctor SJ. Monoclonal anti-TNFa suppresses graft vs Host Disease reactions in an in vitro human skin model. (1994) 6 (2): http://www.ncbi.nlm.nih.gov/pubmed/8031996
  1. Dickinson AM, Sviland L, Carey PJ, Reid MM, Hamilton PJ, Pearson ADJ, Proctor SJ. Skin explant culture as a model for cutaneous graft-versus-host disease in humans. Bone Marrow Transplant (1988) 3:323-329. http://www.ncbi.nlm.nih.gov/pubmed/2971410
  1. Dickinson AM, Wang XN, Sviland J, Jackson G, Taylor P, Dunn J, Proctor SJ. Predicting graft versus host disease in HLA identical bone marrow transplants. A comparison of T cell frequency analysis and a human skin explant model. Transplantation (1998) 66(7):857-863. http://www.ncbi.nlm.nih.gov/pubmed/9798694
  1. Wang XN, Sviland L, Ademokun AJ, Dunn J, Proctor SJ, Dickinson AM Cellular alloreactivity of human cord blood cells detected by T-cell frequency analysis and a human skin explant model. Transplantation (1998) 66(7):903-909. http://www.ncbi.nlm.nih.gov/pubmed/9798701
  1. Sviland L and Dickinson AM. A human skin explant model for predicting graft-versus-host disease following bone marrow transplantation. A Review. J. Clin. Path (1999) 52(12):910-913. http://www.ncbi.nlm.nih.gov/pubmed/10711254
  1. Dickinson AM, Wang XN, Sviland L. In vitro models of graft-versus-host disease: In Cord Blood Characteristics: Role in stem cell transplantation. Eds. Cohen SBA, Gluckman E, Rubinstein P, Madrigal JA. Published by Martin Dunitz (1999) (5) 97-127.
  1. Dickinson AM. Predicting graft versus host disease in bone marrow transplants using in vitro techniques. In the European Commission Publication “Examples of Demonstration Projects in the Life Sciences Programmes-Vol. 3” Eds. Wakolbinger W , Jarvenpaa M, Le Dour O, Norstedt I, Aguilar A. (2000) 49-51.
  1. Hromadníková I, Sedlácek P, Starý J, Cermáková M, Vavrinec J, Stechová K, Dolezalová L, Sviland L, Dickinson AM. An in vitro skin explant assay as a predictive assay for graft-versus-host disease in a cohort of pediatric transplants. Pediatr Transplantation (2001) 5:258-265. http://www.ncbi.nlm.nih.gov/pubmed/11472604
  1. Hromadníková I, Sedlácek P, Starý J, Vavrinek J, Cermáková M, Stechova K, Houbova B, Vitek A,. Sajdova J, Sviland L, Dickinson AM. Skin explant assay – an in vitro graft versus host disease predictive test for allogeneic haematopoietic stem cell transplant. Journal of Czech Physicians (2001) ;140(3):73-78.
  1. Sviland L, Hromadníková I, Sedlácek P, Cermáková M, Stechová K, Holler E, Eissner G, Schultz U, Kolb HJ, Jackson GH, Wang XN, Dickinson AM. Histological correlation between different centres using the skin explant model to predict graft-versus-host disease following bone marrow transplantation. Hum Immunol (2001), 62(11):1277-1281. http://www.ncbi.nlm.nih.gov/pubmed/11704291
  1. Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN, Haanen JBAG, Mutis T, Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells for minor histocompatibility antigens. Nature Med (2002) 8(4):410-414. http://www.ncbi.nlm.nih.gov/pubmed/11927949
  1. 14. Jarvis M, Schulz U, Dickinson AM, Sviland L, Jackson G, Konur R, Wang XN, Hromadníková I, Kolb HJ, Eissner G, Holler E. The detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions. Journal of Clinical Pathology (2002) 55(2):127-132. http://www.ncbi.nlm.nih.gov/pubmed/11865008
  1. Wang XN, Lange C, Schulz U, Sviland L, Eissner G, Oliver KM, Jackson GH, Holler E, Dickinson AM. IL-10 modulation of alloreactivity and graft versus host reactions Transplantation (2002), 74(6):772-778. http://www.ncbi.nlm.nih.gov/pubmed/12364854
  1. Wang XN, Collin M, Sviland L, Marshall S, Jackson GH, Schulz U, Holler E, Karrer S, Greinix H, Elahi F, Hromadníková I, Dickinson AM. Skin explant model of human graft-versus-host disease: Prediction of clinical outcome and correlation with biological risk factors. Biol Blood Marrow Transplant (2006) 12(2):152-159. http://www.ncbi.nlm.nih.gov/pubmed/16443513
  1. Ruffin N, Ahmed SS, Osorio LM, et al. The involvement of epithelial Fas in a human model of graft versus host disease. Transplantation (2011) 91(9):946-51. http://www.ncbi.nlm.nih.gov/pubmed/21403589
  1. Mavin E, Ahmed SS, O’Boyle G, Turner B, Douglass S, Norden J, Collin M, Ali S, Dickinson A, Wang XN. Regulatory T cells inhibit CD8(+) T-cell tissue invasion in human skin graft-versus-host reactions. Transplantation. 2012 Sep