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Reference and Patents

Patents:

European Patent Predicting Allergic Reactions – EP2524227B1

US Patent Predicting Allergic Reactions – US9651544 B2

US Patent 3D Skin Model – US10408848B2

Patents Pending:

European Patent 3D Skin Model – EP296830A1

 

References:

  1. Dickinson AM, Godden JM, Lanovyk K, and Ahmed SS. Assessing the Safety of Nanomedicines: A Mini Review. Applied Invitro Tocicology 5:114-122 (2019)
  2. Ahmed S, Whritenour J, Ahmed M, Bibby L, Darby L, Wang X, Watson J, Dickinson A. Evaluation of a human in vitro skin test for predicting drug hypersensitivity reactions. Toxicology and Applied Pharmacology 369:39-48 (2019).
  3. Ogese M, Ahmed SS, Alfirevic A, Betts C, Dickinson AM, Falkner L, French N, Gibson A, Hrishfield GM, Kammuller ME, Meng X, Martin SF, Musette P, Norris A, Pirmohamed M, Park BK, Purcell AW, Spraggs CF, Whritenour J, Naisbitt DJ. New approaches to investigate drug-induced hypersensitivity. Chem. Res. Toxicol. 2017, 30, 239-259.
  4. Qesari M, Richter A, Ogonek J, Mischak-Weissinger E, Wang XN, Dickinson AM. Cytomegalovirus-Specific T Cells Isolated by IFN-γ Secretion Assay Do Not Induce Significant Graft-Versus-Host Reactions In Vitro. Transplantation. 2016, 100(11), 2352-2361
  5. Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. An in vitro human skin test for assessing sensitization potential. J Applied Tox (2016) 36:669-684. https://www.ncbi.nlm.nih.gov/pubmed/26251951
  6. Mavin E, Ahmed SS, O’Boyle G, Turner B, Douglass S, Norden J, Collin M, Ali S, Dickinson A, Wang XN. Regulatory T cells inhibit CD8(+) T-cell tissue invasion in human skin graft-versus-host reactions. Transplantation. 2012 Sep
  7. Ruffin N, Ahmed SS, Osorio LM, et al. The involvement of epithelial Fas in a human model of graft versus host disease. Transplantation (2011) 91(9):946-51. http://www.ncbi.nlm.nih.gov/pubmed/21403589
  8. Wang XN, Collin M, Sviland L, Marshall S, Jackson GH, Schulz U, Holler E, Karrer S, Greinix H, Elahi F, Hromadníková I, Dickinson AM. Skin explant model of human graft-versus-host disease: Prediction of clinical outcome and correlation with biological risk factors. Biol Blood Marrow Transplant (2006) 12(2):152-159. http://www.ncbi.nlm.nih.gov/pubmed/16443513
  9. Wang XN, Lange C, Schulz U, Sviland L, Eissner G, Oliver KM, Jackson GH, Holler E, Dickinson AM. IL-10 modulation of alloreactivity and graft versus host reactions Transplantation (2002), 74(6):772-778. http://www.ncbi.nlm.nih.gov/pubmed/12364854
  10. Jarvis M, Schulz U, Dickinson AM, Sviland L, Jackson G, Konur R, Wang XN, Hromadníková I, Kolb HJ, Eissner G, Holler E. The detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions. Journal of Clinical Pathology (2002) 55(2):127-132. http://www.ncbi.nlm.nih.gov/pubmed/11865008
  11. Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN, Haanen JBAG, Mutis T, Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells for minor histocompatibility antigens. Nature Med (2002) 8(4):410-414. http://www.ncbi.nlm.nih.gov/pubmed/11927949
  12. Sviland L, Hromadníková I, Sedlácek P, Cermáková M, Stechová K, Holler E, Eissner G, Schultz U, Kolb HJ, Jackson GH, Wang XN, Dickinson AM. Histological correlation between different centres using the skin explant model to predict graft-versus-host disease following bone marrow transplantation. Hum Immunol (2001), 62(11):1277-1281. http://www.ncbi.nlm.nih.gov/pubmed/11704291
  13. Hromadníková I, Sedlácek P, Starý J, Vavrinek J, Cermáková M, Stechova K, Houbova B, Vitek A,. Sajdova J, Sviland L, Dickinson AM. Skin explant assay – an in vitro graft versus host disease predictive test for allogeneic haematopoietic stem cell transplant. Journal of Czech Physicians (2001) ;140(3):73-78.
  14. Hromadníková I, Sedlácek P, Starý J, Cermáková M, Vavrinec J, Stechová K, Dolezalová L, Sviland L, Dickinson AM. An in vitro skin explant assay as a predictive assay for graft-versus-host disease in a cohort of pediatric transplants. Pediatr Transplantation (2001) 5:258-265. http://www.ncbi.nlm.nih.gov/pubmed/11472604
  15. Dickinson AM. Predicting graft versus host disease in bone marrow transplants using in vitro techniques. In the European Commission Publication “Examples of Demonstration Projects in the Life Sciences Programmes-Vol. 3” Eds. Wakolbinger W , Jarvenpaa M, Le Dour O, Norstedt I, Aguilar A. (2000) 49-51.
  16. Dickinson AM, Wang XN, Sviland L. In vitro models of graft-versus-host disease: In Cord Blood Characteristics: Role in stem cell transplantation. Eds. Cohen SBA, Gluckman E, Rubinstein P, Madrigal JA. Published by Martin Dunitz (1999) (5) 97-127.
  17. Sviland L and Dickinson AM. A human skin explant model for predicting graft-versus-host disease following bone marrow transplantation. A Review. J. Clin. Path (1999) 52(12):910-913. http://www.ncbi.nlm.nih.gov/pubmed/10711254
  18. Wang XN, Sviland L, Ademokun AJ, Dunn J, Proctor SJ, Dickinson AM Cellular alloreactivity of human cord blood cells detected by T-cell frequency analysis and a human skin explant model. Transplantation (1998) 66(7):903-909. http://www.ncbi.nlm.nih.gov/pubmed/9798701
  19. Dickinson AM, Wang XN, Sviland J, Jackson G, Taylor P, Dunn J, Proctor SJ. Predicting graft versus host disease in HLA identical bone marrow transplants. A comparison of T cell frequency analysis and a human skin explant model. Transplantation (1998) 66(7):857-863. http://www.ncbi.nlm.nih.gov/pubmed/9798694
  20. Dickinson AM,Sviland L, Jackson G, Dunn, Stephens, Proctor SJ. Monoclonal anti-TNFa suppresses graft vs Host Disease reactions in an in vitro human skin model. (1994) 6 (2): http://www.ncbi.nlm.nih.gov/pubmed/8031996
  21. Dickinson AM, Sviland L, Jackson G, Usher P, Taylor P, Dunn J, Hamilton PJ, Proctor SJ. Cytokine involvement in predicting clinical graft versus host disease (GvHD) in allogeneic bone marrow transplant recipients. Bone Marrow Transplant (1994) 13(1):65-70. http://www.ncbi.nlm.nih.gov/pubmed/8019455
  22. Dickinson AM, Sviland L, Dunn J, Carey P, Proctor SJ. Demonstration of direct involvement of cytokines in graft versus host reactions using an in vitro human skin explant model. Bone Marrow Transplant (1991) 7:209- 216. http://www.ncbi.nlm.nih.gov/pubmed/1829387
  23. Sviland L, Dickinson AM, Carey PJ, Pearson ADJ, Proctor SJ. An in vitro predictive test for clinical graft versus host disease in allogeneic bone marrow transplant recipients. Bone Marrow Transplant (1990) 5:105-109. http://www.ncbi.nlm.nih.gov/pubmed/1968774
  24. Dickinson AM, Sviland L, Carey PJ, Reid MM, Hamilton PJ, Pearson ADJ, Proctor SJ. Skin explant culture as a model for cutaneous graft-versus-host disease in humans. Bone Marrow Transplant (1988) 3:323-329. http://www.ncbi.nlm.nih.gov/pubmed/2971410

 

 

 

 

 

 

 

 

 

 

 

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